Description

Research Overview

Tirz is a dual GIP/GLP-1 receptor co-agonist — a class of incretin-based research compounds that simultaneously engage both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor. This dual receptor activity distinguishes it mechanistically from single-receptor GLP-1 agonists and has made it a significant subject of metabolic research.

As a 39-amino acid synthetic peptide engineered from a GIP peptide backbone, Tirz is studied in preclinical and clinical metabolic models for its role in glycemic regulation, energy homeostasis, and adipose tissue biology.

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Scientific Background

Tirz achieves GIP receptor affinity comparable to native GIP while binding the GLP-1 receptor with approximately 5-fold weaker affinity than native GLP-1 — a pharmacological balance that appears to drive enhanced metabolic outcomes relative to selective GLP-1 agonism alone. Research has demonstrated that GIP and GLP-1 receptor co-activation produces synergistic effects on insulin secretion, appetite suppression, and body weight regulation.

The SURPASS clinical trial program, comprising five large-scale randomized controlled trials, has established Tirz as one of the most extensively characterized incretin compounds in metabolic research, with ongoing investigation expanding into cardiovascular outcomes, hepatic steatosis, and neurological applications.

Molecular Information

• Peptide Type: Dual GIP/GLP-1 receptor co-agonist (“twincretin”)
• Amino Acid Length: 39 amino acids (modified GIP backbone)
• Primary Targets: GIP receptor and GLP-1 receptor (incretin signaling)
• Research Classification: Dual incretin metabolic research compound
• Purity: ≥99% (HPLC verified)
• Appearance: Lyophilized powder
• Storage: Refrigerated (2–8°C)

Quality & Analytical Standards

Each batch undergoes analytical verification to confirm identity and purity. Batch-specific Certificates of Analysis (COA) are maintained for all production runs and available upon request.

Research Use Only

This product is intended strictly for laboratory research purposes. Not approved for human or veterinary use. No therapeutic or diagnostic claims are made. BioStrata Research supplies materials exclusively for qualified research and analytical applications.