Reta GLP-3

Description

Research Overview

Reta is a triple hormone receptor agonist targeting the GLP-1, GIP, and glucagon (GCG) receptors simultaneously — representing the next generation of incretin-based metabolic research compounds beyond dual agonists. As a 39-amino acid peptide linked to a C20 fatty diacid moiety that extends its pharmacokinetic half-life, Reta is studied for its comprehensive engagement of three distinct hormonal pathways involved in energy homeostasis. This triple-receptor activity places Reta at the forefront of metabolic signaling research, enabling investigators to study the additive and synergistic effects of GLP-1, GIP, and glucagon receptor co-activation across a range of metabolic and hepatic research models.

Explore related peptide research in our Research Library, or dive deeper into detailed findings in the Full Research Overview.

Scientific Background

The rationale for triple agonism arises from the complementary roles of the three targeted receptors: GLP-1 receptor activation suppresses appetite and stimulates insulin secretion; GIP receptor activation potentiates insulin response and modulates adipose tissue biology; glucagon receptor activation increases energy expenditure, promotes lipolysis, and — critically — engages glucagon receptors in the liver, which are absent for GLP-1 and GIP, providing direct hepatic metabolic effects.

Phase 2 clinical trial data published in the New England Journal of Medicine demonstrated mean weight reductions of up to 24.2% at 48 weeks with the highest dose of Retatrutide, with continued weight loss trajectory observed throughout the trial period and no plateau — findings that have generated substantial scientific interest in triple incretin biology.

Molecular Information

• Peptide Type: Triple GIP/GLP-1/Glucagon receptor agonist
• Amino Acid Length: 39 amino acids (modified GIP backbone with C20 fatty diacid moiety)
• Primary Targets: GIP receptor, GLP-1 receptor, and Glucagon receptor
• Research Classification: Triple incretin metabolic research compound
• Purity: ≥99% (HPLC verified)
• Appearance: Lyophilized powder
• Storage: Refrigerated (2–8°C)

Quality & Analytical Standards

Each batch undergoes analytical verification to confirm identity and purity. Batch-specific Certificates of Analysis (COA) are maintained for all production runs and available upon request.

Research Use Only

This product is intended strictly for laboratory research purposes. Not approved for human or veterinary use. No therapeutic or diagnostic claims are made. BioStrata Research supplies materials exclusively for qualified research and analytical applications.