Melanotan 2 | 10mg

Description

Research Overview

Melanotan II is a synthetic cyclic analog of alpha-melanocyte stimulating hormone (α-MSH), a naturally occurring peptide involved in melanogenesis and melanocortin receptor signaling. Originally developed by researchers at the University of Arizona for experimental investigation of melanocortin receptor biology, it has since become a widely used tool in preclinical research examining pigmentation mechanisms, neuroendocrine signaling, and energy regulation.

Because natural α-MSH has a very short biological half-life, Melanotan II was engineered as a more metabolically stable analog, making it suitable for controlled experimental models that require sustained receptor engagement.

Explore related peptide research in our Research Library, or dive deeper into the full Melanotan II Research Overview.

Scientific Background

Melanotan II primarily functions through activation of melanocortin receptors (MC1R, MC3R, MC4R, MC5R), a family of G protein-coupled receptors that respond to POMC-derived peptides. Activation of MC1R in melanocyte systems stimulates melanogenesis and the production of eumelanin pigments. Its ability to cross the blood-brain barrier has also made it relevant in neuroendocrine research examining appetite regulation, energy expenditure, and hypothalamic signaling pathways.

Laboratory studies using cell cultures and receptor binding assays continue to refine the understanding of how melanocortin receptor subtypes interact with synthetic analogs, contributing to broader research into pigmentation biology and metabolic neuroendocrinology.

Molecular Information

• Peptide Type: Synthetic cyclic α-MSH analog
• Structure: Cyclic heptapeptide, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2
• Primary Receptors: MC1R, MC3R, MC4R, MC5R (melanocortin receptor family)
• Research Classification: Melanocortin signaling and pigmentation research compound

Quality & Compliance

Each batch undergoes analytical verification to confirm identity and purity, and batch-specific Certificates of Analysis (COA) are maintained for every production run. This product is supplied strictly for laboratory research and is not for human or veterinary use.