IGF-LR3 – 1mg

Description

Research Overview

IGF-LR3 (Insulin-like Growth Factor-1 Long Arg3) is a synthetic analog of insulin-like growth factor-1 (IGF-1), engineered with an extended amino acid sequence and a substitution at the third position to enhance stability and reduce binding to IGF-binding proteins (IGFBPs). In controlled laboratory settings, IGF-LR3 is studied for its role in cellular growth signaling, protein synthesis pathways, and nutrient partitioning mechanisms.

Due to its reduced affinity for IGFBPs and prolonged activity profile compared to native IGF-1, IGF-LR3 demonstrates extended receptor interaction in vitro, making it a valuable compound for research involving cell proliferation, differentiation, and metabolic signaling pathways.

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Scientific Background

IGF-LR3 was developed as a modified form of IGF-1 to improve bioavailability and functional stability in experimental models. The addition of a 13-amino acid extension at the N-terminus, along with the Arg3 substitution, reduces its binding to IGF-binding proteins, allowing for greater interaction with the IGF-1 receptor (IGF-1R).

Preclinical research has explored IGF-LR3 in the context of intracellular signaling pathways such as PI3K/Akt and MAPK/ERK, which are associated with cellular growth, survival, and metabolic regulation. Studies have also examined its effects on glucose uptake, amino acid transport, and tissue-specific cellular responses under controlled laboratory conditions.

Its enhanced stability and receptor activity have made IGF-LR3 a commonly studied analog in research focused on growth factor signaling and cellular adaptation mechanisms.

Molecular Information

• Peptide Type: Synthetic IGF-1 analog (Long Arg3 variant)
• Amino Acid Length: 83 amino acids
• Modification: Arg3 substitution + N-terminal 13-amino acid extension
• Research Classification: Experimental growth factor analog
• Purity: ≥99% (HPLC verified)
• Appearance: Lyophilized powder
• Storage: Refrigerated (2–8°C); stable ≥30 days post-reconstitution at 4°C

Quality & Analytical Standards

Each batch undergoes analytical verification to confirm identity and purity. Batch-specific Certificates of Analysis (COA) are maintained for all production runs and available upon request.

Research Use Only

This product is intended strictly for laboratory research purposes. Not approved for human or veterinary use. No therapeutic or diagnostic claims are made. BioStrata Research supplies materials exclusively for qualified research and analytical applications.