Tirz GLP-2 / GIP

Description

Research Overview

Tirz is a dual GIP/GLP-1 receptor co-agonist, part of a class of incretin-based research compounds that simultaneously engage both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor. This dual receptor activity distinguishes it mechanistically from single-receptor GLP-1 agonists and has made it a significant subject of metabolic research.

As a 39-amino acid synthetic peptide engineered from a GIP peptide backbone, Tirz is studied in preclinical metabolic models for its role in glycemic regulation, energy homeostasis, and adipose tissue biology.

Explore related peptide research in our Research Library, or dive deeper into the full Tirz Research Overview.

Scientific Background

Tirz achieves GIP receptor affinity comparable to native GIP while binding the GLP-1 receptor with approximately 5-fold weaker affinity than native GLP-1. This imbalanced pharmacology appears to drive enhanced metabolic outcomes relative to selective GLP-1 agonism alone. Research has demonstrated that GIP and GLP-1 receptor co-activation produces synergistic effects on insulin secretion, appetite signaling, and energy balance.

Tirz is now one of the most extensively characterized incretin compounds in the published literature, with ongoing research expanding into hepatic lipid metabolism, cardiometabolic signaling, and the neurological effects of dual incretin receptor activation.

Molecular Information

• Peptide Type: Dual GIP/GLP-1 receptor co-agonist (“twincretin”)
• Amino Acid Length: 39 amino acids (modified GIP backbone)
• Key Modifications: Aib substitutions at positions 2 and 13; C20 fatty diacid side chain at Lys20
• Primary Targets: GIP receptor and GLP-1 receptor (incretin signaling)
• Research Classification: Dual incretin metabolic research compound

Quality & Compliance

Each batch undergoes analytical verification to confirm identity and purity, and batch-specific Certificates of Analysis (COA) are maintained for every production run. This product is supplied strictly for laboratory research and is not for human or veterinary use.