Description
Research Overview
TB-500 is a synthetic heptapeptide corresponding to the actin-binding motif found within Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid peptide encoded by the TMSB4X gene. In laboratory research, TB-500 is used as a molecular tool to study cytoskeletal remodeling, cell morphology, and actin-mediated signaling pathways.
Its primary mechanism involves sequestering G-actin monomers, which influences the balance between free and polymerized actin. This regulatory process is critical for cell migration, structural reorganization, and adaptive tissue responses in preclinical models.
Explore related peptide research in our Research Library, or dive deeper into the full TB-500 Research Overview.
Scientific Background
Thymosin Beta-4, from which TB-500 is derived, is one of the most extensively studied peptides in regenerative biology. Preclinical investigations across multiple tissue types have reported diverse biological activities associated with TB-500, including modulation of cell migration, angiogenic signaling pathways, and extracellular matrix organization.
Research models examining cardiac, musculoskeletal, epithelial, and endothelial tissues have used TB-500 to explore how actin dynamics influence cellular repair mechanisms and structural reorganization. Gene expression studies indicate that the Thymosin Beta-4 gene is activated as one of the early response genes during tissue disruption.
Molecular Information
- Peptide Type: Synthetic actin-binding heptapeptide (Thymosin Beta-4 fragment)
- Peptide Sequence: Ac-LKKTETQ
- Molecular Weight: 889.018 g/mol
- Parent Protein: Thymosin Beta-4 (TMSB4X gene)
- Research Classification: Cytoskeletal regulation and tissue remodeling research compound
Quality & Compliance
Each batch undergoes analytical verification to confirm identity and purity, and batch-specific Certificates of Analysis (COA) are maintained for every production run. This product is supplied strictly for laboratory research and is not for human or veterinary use.
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