Description

Research Overview

TB-500 is a synthetic heptapeptide corresponding to the actin-binding motif found within Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid peptide encoded by the TMSB4X gene. In laboratory research, TB-500 is used as a molecular tool to study cytoskeletal remodeling, cell morphology, and actin-mediated signaling pathways.

Its primary mechanism involves sequestering G-actin monomers, influencing the balance between free and polymerized actin — a regulatory process critical for cell migration, structural reorganization, and adaptive tissue responses in preclinical models.

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Scientific Background

Thymosin Beta-4, from which TB-500 is derived, is one of the most extensively studied peptides in regenerative biology. Preclinical investigations across multiple tissue types have reported diverse biological activities associated with TB-500, including modulation of cell migration, angiogenic signaling pathways, and extracellular matrix organization.

Research models examining cardiac, musculoskeletal, epithelial, and endothelial tissues have utilized TB-500 to explore how actin dynamics influence cellular repair mechanisms and structural reorganization. Gene expression studies indicate that the Thymosin Beta-4 gene is activated as one of the early response genes during tissue disruption.

Molecular Information

• Peptide Type: Synthetic actin-binding heptapeptide (Thymosin Beta-4 fragment)
• Peptide Sequence: Ac-LKKTETQ
• Molecular Weight: 889.018 g/mol
• Parent Protein: Thymosin Beta-4 (TMSB4X gene)
• Research Classification: Cytoskeletal regulation and tissue remodeling research compound
• Purity: ≥99% (HPLC verified)
• Appearance: Lyophilized powder
• Storage: Refrigerated (2–8°C)

Quality & Analytical Standards

Each batch undergoes analytical verification to confirm identity and purity. Batch-specific Certificates of Analysis (COA) are maintained for all production runs and available upon request.

Research Use Only

This product is intended strictly for laboratory research purposes. Not approved for human or veterinary use. No therapeutic or diagnostic claims are made. BioStrata Research supplies materials exclusively for qualified research and analytical applications.